The hepatoprotective activity of Ocimum sanctum leaves extract was evaluated in experimentally induced chronic lead toxicity in male wistar rats. The TSP, antioxidant enzymes like CAT, SOD and GPx, gross and histopathologocal examination, immunohistochemical staining and ultrastructural examination of liver were estimated. Lead residues in liver was also measured. The Ocimum sanctum (OS) significantly increased the levels of total serum proteins, CAT, SOD and GPx in liver and lead residues were significantly reduced in Ocimum treated groups. OS significantly minimized the gross and histopathological changes and also reduces the apoptosis in hepatocytes. By the end of experiment in Ocimum treated animals the liver almost coming to its normal appearance. The present experiments suggest that the Ocimum santum exhibited significant hepatoprotective effect on lead induced hepatic damage in rats.
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